Site Loader
Rock Street, San Francisco

This outline will sum up the article titled Interactions of the malaria parasite and its mammalian host. The article aims to analyze the parasite ‘s relationship with the host. It peculiarly addresses the familial facets of the parasite-host relationship. It discusses how new research influences the cognition we have about the relationship. It analyzes the ways that the parasite is able to go on to stay in the host so efficaciously.

Malaria is spread by the Anopheles mosquito when it injects Plasmodium after taking a blood repast from a human host. Sporozoites from the Plasmodium onslaught the hepatocytes of the liver. There are surveies that have shown that the sporozoites pass through the tegument and wander in the organic structure until they reach a blood vas that will let them to make the liver. The surveies besides propose that CD8+ T cells are prompted to respond after the sporozoites are injected into the tegument. These CD8+ T cells kill off the septic hepatocytes in the liver.

We Will Write a Custom Essay Specifically
For You For Only $13.90/page!


order now

Sporozoites have to interrupt the plasma membrane of cells to go an effectual parasite. Three proteins have been discovered that assistance in the sporozoite interrupting the plasma membrane: sporozoite protein indispensable for cell transversal ( SPECT-1 ) , SPECT-2, and phospholipase. Sporozoites that do non hold these particular proteins are non able to go around the organic structure of the host. These missing sporozoites are stationary on the corium of the host. Those sporozoites that are non missing the proteins are able to come in the blood watercourse. The circumsporozoite protein ( CSP ) covers the full sporozoite. The CSP interacts with the Lipo-Hepin sulphate proteoglycans ( HSPG ) that screen hepatocytes. This interaction explains why sporozoites travel chiefly to the liver of the host.

This article discusses a “ switch from migration to productive invasion ” of the parasite. After the sporozoite travels through many hepatocytes, it forms a parasitophorous vacuole. Torgler et Al has demonstrated that the migration of sporozoites through different hepatocytes can bring on inflammatory response that will kill the parasite. As mentioned before, sporozoites missing SPECT are non able to migrate between hepatocytes ; nevertheless, they do organize a parasitophorous vacuole. Surveies have shown that normal sporozoites invade slower than mutant sporozoites. This determination implies that the migratory nature of sporozoites can decelerate the oncoming of the existent infection in the host. There are many proposed causes of the switch to invasion such as: Lipo-Hepin sulphate proteoglycans, derived functions of K and U, and cell surface ligands.

As mentioned before, the sporozoites develop in the liver of the host. Recent research is giving us new penetration on the relationship between Plasmodium and the host at the liver phase. When sporozoites lack cistrons that are upregulated in septic sporozoites ( UIS3, UIS4 ) , the hepatocytes they infect get protection from infection. Some in vitro surveies have noted that UIS3 has a relationship with the liver fatty acid adhering protein. A lessening in the liver fatty acid adhering protein in bend causes a lessening of parasitic development. There appears to be a tendency that lipid bringing is required for the liver phase of the parasite to develop efficaciously. The sporozoites develop into merozoites. A microscopic analysis of gnawers infected with a species of Plasmodium demonstrated that when the merozomes, which are cysts that hold the merozoites, leave the liver of the host whole. This is to protect against the parasite being killed by macrophages.

Merozoites are able to infect ruddy blood cells. The invasion of merozoites into red blood cells is executed in a set of stairss. First, the merozoites attach to the ruddy blood cell in a random manner. The apical terminal of the merozoite ensures attachment to the ruddy blood cell. The merozoite and erythrocyte signifier a tight junction and the merozoite is able to derive entry. The merozoite forms a parasitophorous vacuole and later alterations into a ring phase. The turning merozoites so go through DNA reproduction. Budding of the merozoites takes topographic point and so they release exonemes which allow them to issue. The freshly released merozoites find new environing red blood cells and reiterate the rhythm continuously. Since ruddy blood cells do non let for endocytic and secretory tracts for parasites to take advantage of, Plasmodium utilizes other paths to assist it turn parasitically. During the ring phase of the merozoite, a tubovesicular web is formed. This tubovesicular web increases the surface country of the parasite. The ring phase besides entirely relies on haemoglobin for its diet. A new survey by Chang et al discusses how Plasmodium export component AIDSs in exporting proteins like virulency factors into the red blood cells. One protein the article references is a kinase called FIKK/TSTK. FIKK/TSTK is specifically encoded for parasites. Analyzing the exporting proteins can give us insight on how host limitation alteration evolves, and furthermore the relationship between parasite effecters and the targeted proteins of the host. Harmonizing to research workers, ruddy blood cell theoretical accounts are really of import and can give us more cognition about the proteins and how the Plasmodium develops, which can finally bring forth a more effectual intervention for malaria.

Cerebral malaria has been the focal point of several research undertakings. The research workers are looking to find the familial facets of Plasmodium that control the factors of intellectual malaria. Heme oxygenase-1 ( HO-1 ) is the enzyme that determines whether a host will develop intellectual malaria. Recent surveies have concluded that HO-1 was lower in mice that do develop intellectual malaria, and HO-1 was somewhat higher in mice that are non susceptible to intellectual malaria. When HO-1 was wholly silenced in insusceptible mice, happening of intellectual malaria was significantly increased. Azotic oxide and C monoxide have besides shown to diminish incidence of intellectual malaria.

The research on malaria is really of import on a planetary graduated table. Though malaria is no longer prevalent in the United States, it kills 1000000s of people each twelvemonth in many other states. As a research worker myself, I believe that any new findings get us closer to a more effectual intervention or remedy for a disease. I found that the circumsporozoite protein interaction with proteglycans of hepatocytes to be really interesting. If possible, research workers should experiment a manner to halt this interaction. Stoping this interaction could halt the invasion of the Plasmodium in the liver. In add-on, work on mutating the sporozoites to miss SPECT will halt the Plasmodium from come ining the organic structure wholly, which would be a enormous achievement in malaria research.

Post Author: admin

x

Hi!
I'm Percy!

Would you like to get a custom essay? How about receiving a customized one?

Check it out